Pan Zheng, MD, PhD, Pathologist and Chief Medical Officer with OncoC4, Inc.
Get to know Dr. Pan Zheng, who serves the population of Maryland.
Dr. Zheng co-founded OncoImmune, Inc. and served as its Chief Medical Officer since 2000 until its acquisition by Merck, Inc. Dr. Zheng designed and executed the clinical trials for the company, including most recently a Phase III clinical trial established strong therapeutic efficacy of CD24Fc for hospitalized severe and critical COVID-19 patients. Dr. Zheng continues to lead clinical development in OncoC4, Inc, which is devoted to improving safety and efficacy of cancer immunotherapy. A current First in Human Phase IA/IB clinical trial testing a first pH-sensitive and recycling anti-CTLA-4 antibody ONC-392 is recruiting patients with metastatic solid tumors and non-small cell lung cancer. Pre-clinical studies demonstrate that this novel anti-CTLA-4 antibody is highly effective for immunotherapy but largely devoid of immune related toxicities.
Dr. Pan Zheng was on faculty in a number of academic institutes including the Ohio State University, University of Michigan, Children’s National Medical Center and Institute of Human Virology and Department of Surgery, University of Maryland School of Medicine. Dr. Zheng’s academic research focuses on immuno-oncology and inflammation. Dr. Zheng was trained in anatomic and clinical pathology and is a board-certified Physician with the American Board of Pathology.
In regards to her education, she graduated with her medical degree from Peking Union Medical College in 1987 and PhD degree in Immunobiology from Yale University in 1994, followed by her Anatomic and Clinical Pathology residency with the NYU School of Medicine from 1994 to 1998.
Dr. Zheng’s research includes tumor immunology, pathology, and stem cell biology. As a physician scientist, she specializes in translational research and has co-invented new approaches for immunotherapy of cancer, autoimmune diseases and stem cell aging, as well as therapeutic elimination of cancer stem cells.
A pathologist studies fluids, tissues, or organs taken from the body. Pathologists often work with a surgically removed sample of diseased tissue, called a biopsy. The pathological examination of an entire body is an autopsy. Pathologists are often involved in the diagnosis of illness. A pathologist may examine a sample of tissue for a virus, bacteria, or other infectious agents. The vast majority of cancer diagnoses are made by, or in conjunction with, a pathologist. Pathologists may also help guide the course of treatment. For example, a pathologist may analyze blood samples, helping to monitor and track the progression of a bloodborne illness.
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